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KMID : 0604520210470010075
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Journal of the Society of Cosmetic Scientists of Korea
2021 Volume.47 No. 1 p.75 ~ p.84
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Protective Effects of Novel Tripeptide Against Particulate Matter-induced Damage in HaCaT Keratinocytes
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Lee Eung-Ji
Kang Ha-Na
Hwang Bo-Byeol
Lee Young-Min
Chung Yong-Ji
Kim Eun-Mi
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Abstract
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In this study, we investigated inhibitory effect of Tripeptide against particulate matter (PM)-induced damage in human keratinocytes. PM-induced cell death was inhibited by Tripeptide and the activity of aryl hydrocarbon receptor (AhR) also inhibited by Tripeptide resulting in reduced expression of its downstream targets, cytochrome P450 family 1 subfamily A member 1 (CYP1A1) and cyclooxygenase-2 (COX-2), which are responsible for toxic metabolites production and inflammation. Furthermore, PM-induced expressions of pro-inflammatory cytokines, matrix metalloproteinase-1 (MMP-1) and apoptosis-related factors were decreased by anti-oxidant activity of Tripeptide. From these results, it has been shown that the Tripeptide has protective effect against PM-induced skin damage not only through the inhibiting of keratinocyte death but also through the inhibiting the secretion of several damage-inducing factors to adjacent skin tissue. And the results suggested that Tripeptide with anti-pollution effect could be applied as a new functional cosmetic material.
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KEYWORD
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tripeptide, particulate matter, ambient air pollution, aryl hydrocarbon receptor, reactive oxygen species
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